About the LONI Resource

The guiding mission of the LONI Resource is to improve our understanding of the brain in health and disease through the comprehensive and quantitative analysis of images of its structure and functions. Our goal is to develop tools, algorithms and approaches to achieve this mission, to enhance collaboration and dissemination of these solutions and to train investigators in their use.

The LONI Resource aims to continue the development and refinement of a multidimensional modeling environment in which the three spatial dimensions typically used in neuroimaging and brain mapping are extended to permit their examination within the framework of changing morphology. This framework extends the static measurement of the brain to the dynamic worlds of development, maturation, aging, and pathology.

The core research of the LONI Resource is centered on four specific areas: Image Processing and Segmentation, Deformation Morphometry and Registration, Atlasing, and Informatics. These four core research projects form a well-integrated program to characterize, measure and model both static and dynamic patterns of structural and functional changes in brain.

Our research program is centered on the fundamental recognition that anatomy is not static. We are able to accommodate a changing anatomic framework such as with developmental, neurodegenerative or other processes, by providing a more comprehensive understanding of the nature and extent of these processes.

The overall specific aims of this proposal are to conduct neuroimaging research and development on computational anatomy and multidimensional modeling and to further develop our neuroimaging Resource to facilitate collaborations, disseminate techniques and information and train investigators in their use.